Exploration of gene expression signature for human coronary artery endothelial cells in response to inhibition of myocyte enhancer factor 2A

Myocyte enhancer factor 2A (MEF2A) is a crucial transcritional activator which plays diverse roles in the control of cell growth, survival, apoptosis and inflammation etc. To expore the gene expression signature of human coronary artery endothelial cells (HCAEC) in reponse to inhibition of MEF2A， we have employed whole genome microarray expression profiling as a discovery platform to identify genes with important functional role in HCAEC. Three independent groups of HCAEC transfected with MEF2A specific siRNA were separately performed. Three MEF2A specific siRNA groups were indicated as 1527-1, 1527-2 and 1527-3, and the mixed control group was designated as NC. Alteration in gene expression in response to inhibition of MEF2A was measured at 72 hours after transfection with MEF2A specific siRNA and negative control siRNA.