Functions of genes encoded in T6SS locus of <i>V. cholerae</i> V52.

aclpV and VCA0118 mutants exhibited bacterial killing activity but at a significantly lower level than wild type. bVCA0122 enhances Hcp expression and secretion. The VCA0122 mutant exhibited a slightly lower level of Hcp expression than wild type. chcp-1 and hcp-2 fully complement each other. Their requirement for virulence is only observed in the context of the double knock-out. dvgrG-1 and vgrG-3 are able to complement each other for E. coli killing activity only. The double mutant is avirulent toward E. coli.