IDH1 R132H in complex with IDH125

IDH1 R132H in complex with IDH125 Descriptor: (4S)-3-(2-{[(1S)-1-phenylethyl]amino}pyrimidin-4-yl)-4-(propan-2-yl)-1,3-oxazolidin-2-one, CITRATE ANION, Isocitrate dehydrogenase [NADP] cytoplasmic, ... Authors: Xie, X, Kulathila, R. Deposit date: 2016-08-05 Release date: 2017-02-08 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25, 2017与IDH125形成复合物的IDH1 R132H的描述信息：(4S)-3-(2-{[(1S)-1-苯乙基]氨基}嘧啶-4-基)-4-异丙基-1,3-恶唑烷-2-酮、柠檬酸根阴离子、胞质NADP依赖性异柠檬酸脱氢酶…… 作者：Xie, X、Kulathila, R. 存档日期：2016-08-05 发布日期：2017-02-08 最后修改日期：2024-03-06 实验方法：X射线衍射（分辨率2.34埃） 引用文献：变构突变IDH1抑制剂揭示IDH1突变体与亚型选择性机制。《Structure》，第25卷，2017年