Crystal structure of a mutated catalytic domain of Human MMP12 in complex with RXP470
收藏Protein Data Bank Japan2024-01-10 更新2026-03-21 收录
下载链接：
https://pdbj.org/mine/summary/5czm
下载链接
链接失效反馈官方服务：
资源简介：
Crystal structure of a mutated catalytic domain of Human MMP12 in complex with RXP470 Descriptor: CALCIUM ION, Macrophage metalloelastase, N-[(2S)-3-[(S)-(4-bromophenyl)(hydroxy)phosphoryl]-2-{[3-(3'-chlorobiphenyl-4-yl)-1,2-oxazol-5-yl]methyl}propanoyl]-L-alpha-glutamyl-L-alpha-glutamine, ... Authors: Rouanet-Mehouas, C, Roselia, L, Devel, L, Dive, V, Stura, E.A. Deposit date: 2015-07-31 Release date: 2016-08-10 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.303 Å) Cite: Zinc-Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity. J. Med. Chem., 60, 2017
人源基质金属蛋白酶12（Human MMP12）突变催化结构域与RXP470的复合物晶体结构
描述：钙离子、巨噬细胞金属弹性蛋白酶、N-[(2S)-3-[(S)-(4-溴苯基)(羟基)磷酰基]-2-{[3-(3'-氯联苯-4-基)-1,2-恶唑-5-基]甲基}丙酰基]-L-α-谷氨酰-L-α-谷氨酰胺等
作者：Rouanet-Mehouas, C、Roselia, L、Devel, L、Dive, V、Stura, E.A.
提交日期：2015-07-31
发布日期：2016-08-10
最后修改日期：2024-01-10
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.303埃
引用文献：《锌金属蛋白酶抑制剂：评估锌结合基团在效力与选择性中的复杂作用》，《药物化学杂志》（J. Med. Chem.），第60卷，2017年
创建时间：
2015-07-31
