Fatal outcome of chikungunya virus infection in Brazil

Abstract

Background
Chikungunya virus (CHIKV) emerged in the Americas in 2013 and has caused ~2.1 million cases and over 600 deaths. A retrospective investigation was undertaken to describe clinical, epidemiological and virus genomic features associated with deaths caused by CHIKV in Ceará state, northeast Brazil.

Methods
Sera, cerebrospinal fluid (CSF) and tissue samples from 100 fatal cases with suspected arbovirus infection were tested for CHIKV, dengue (DENV) and Zika virus (ZIKV). Clinical, epidemiological and death reports were obtained for patients with confirmed CHIKV infection. Logistic regression analysis was undertaken to identify independent factors associated with risk of death during CHIKV infection. Phylogenetic analysis was conducted using whole genomes from a subset of cases.

Results
6...

摘要

背景
基孔肯雅病毒（Chikungunya virus, CHIKV）于2013年传入美洲地区，迄今已造成约210万例感染病例，超过600例死亡。本研究开展回顾性调查，旨在描述巴西东北部塞阿拉州基孔肯雅病毒致死病例相关的临床、流行病学及病毒基因组学特征。

方法
本研究对100例疑似虫媒病毒感染的致死病例的血清、脑脊液（cerebrospinal fluid, CSF）及组织样本开展检测，以筛查基孔肯雅病毒、登革病毒（dengue virus, DENV）与寨卡病毒（Zika virus, ZIKV）感染。针对确诊基孔肯雅病毒感染的患者，收集其临床、流行病学及死亡相关报告资料。采用logistic回归分析，明确基孔肯雅病毒感染期间与死亡风险相关的独立影响因素。选取部分病例的全基因组序列开展系统发育分析。

结果
6...