相关数据集
ChIPSeq of MV4;11 cell treated with SGC0946 for 8 hours and washout
Central to the molecular pathogenesis of MLL leukaemia is the abnormal co-optation of members of transcription complexes including disrupter of telomeric silencing 1-like (DOT1L) and bromodomain conta
NIAID Data Ecosystem80
Mus musculus strain:C57BL/6 Transcriptome or Gene expression. Mus musculus strain:C57BL/6
The purpose of the study is to identify the role of ALOX5 in acute myeloid leukemia
NIAID Data Ecosystem50
Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias. Homo sapiens
High expression of the ETS family transcription factor ERG is associated with poor clinical outcome in acute myeloid leukemia (AML) and acute T-cell lymphoblastic leukemia (T-ALL). In murine models, h
NIAID Data Ecosystem30
Chromatin accessibility promotes hematopoietic and leukemia stem cell activity [RNA-seq]
In this project, we studied how the nucleosome binding protein HMGN1 affects myeloid differentiation and hematopoietic and leukemia stem cell activity Overall design: RNA-seq in primary hematopoietic
NIAID Data Ecosystem70
Core transcriptional regulatory circuit controlled by the tal1 complex in human t-cell acute lymphoblastic leukemia (Subseries)
The oncogenic transcription factor TAL1/SCL is aberrantly overexpressed in over 40% of cases of T-cell acute lymphoblastic leukemia (T-ALL), emphasizing the importance of the TAL1-regulated transcript
NIAID Data Ecosystem40
