Targeting intermolecular interactions to reduce viscosity in monoclonal antibody formulations: Viscosity-reducing additives analysis

The table is the supporting information for a review journal article describing literature about additives that reduce the viscosity of monoclonal antibody (mAb) formulations. The table includes compound names, chemical descriptors of these compounds (SlogP, TPSA (total polar surface area), Average molecular weight, Number of Rotatable Bonds, Number of Hydrogen Bond Donors, Number of Hydrogen Bond Acceptors, Number of Hetero Atoms, Number of Aromatic Rings, Fraction of CSP3), the concentration of the compound that was used in the experiment and viscosity reduction [%]. The latter describes the percentage by which the viscosity of the mAb formulation was reduced when the compound was added relative to the viscosity of the formulation without the added compound. This data was used to find correlation between the molecular descriptors of the compounds and their viscosity-reducing effect as described in the journal article.本表格为一篇综述类期刊文章的支撑补充材料，该综述梳理了有关可降低单克隆抗体（monoclonal antibody, mAb）制剂黏度的添加剂的相关研究文献。本表格涵盖以下信息：添加剂的化合物名称、各化合物的化学描述符（SlogP、总极性表面积（total polar surface area，TPSA）、平均相对分子质量、可旋转键数、氢键供体数目、氢键受体数目、杂原子数目、芳香环数目、sp3杂化碳占比）、实验中所用添加剂的浓度，以及黏度降低率（%）。此处的黏度降低率指：相较于未添加该化合物的制剂黏度，添加该化合物后单克隆抗体制剂的黏度降低的百分比。如该期刊文章所述，本数据集被用于探究添加剂的分子描述符与其降黏效果之间的相关性。