Meta-analysis summary statistics of residualized apolipoprotein B
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Title: Genome-wide association study for residualized-apolipoprotein B elucidates the role of apolipoprotein B in coronary artery disease risk Citation: Zhang et al., Nature Communications (2026) [Reference] Human reference genome: GRCh38 / hg38 [Column dictionary] Variant: variant chromosome and genomic position (GRCh38/hg38) A2: Reference allele A1: Alternate (effect) allele A1FREQ: Alternate allele frequency Beta: Effect size for the lipid trait (per A1 allele) SE: Standard error of beta Z: Z-score of beta P: P-value for association P_hetero: Heterogeneity P-value across studies N_studies: Total number of studies included in meta-analysis N_samples: Total number of individuals included in meta-analysis Effects: Direction of effect per participating cohort (+ = BETA > 0, - = BETA < 0; first effect = UKB, second effect = MGBB) LOG10P: Negative log10 P-value [Contact] Selena Zhang (zhangsel@broadinstitute.org; selena_zhang@hms.harvard.edu)
标题:针对残差校正载脂蛋白B的全基因组关联研究揭示载脂蛋白B在冠心病发病风险中的作用 引用:Zhang 等人,《Nature Communications》,2026年 【参考资料】 人类参考基因组:GRCh38 / hg38 【列字段说明】 变异体(Variant):变异体所在染色体及基因组位置(GRCh38/hg38) 参考等位基因(A2):参考等位基因 替代(效应)等位基因(A1):替代(效应)等位基因 替代等位基因频率(A1FREQ):替代等位基因频率 效应量(Beta):脂质性状的效应量(每携带1个A1等位基因) 标准误(SE):Beta的标准误 Z得分(Z):Beta的Z得分 关联P值(P):关联分析的P值 跨研究异质性P值(P_hetero):跨研究异质性P值 荟萃分析纳入总研究数(N_studies):荟萃分析纳入的总研究数量 荟萃分析纳入总个体数(N_samples):荟萃分析纳入的总个体数量 效应方向(Effects):各参与队列的效应方向(+ 表示 Beta > 0,- 表示 Beta < 0;第一个效应为英国生物库(UKB),第二个为MGBB) 负对数10转换P值(LOG10P):负对数10转换后的P值 【联系人】 Selena Zhang(电子邮箱:zhangsel@broadinstitute.org; selena_zhang@hms.harvard.edu)



