Neutralization titers in sera of 30 secondary dengue cases 12 months post-infection.

a, Secondary DENV infection was determined as described in Methods.bDF, Dengue Fever; DHF, Dengue Hemorrhagic Fever; DSS, Dengue Shock Syndrome.cCurrent infecting serotype was determined by RT-PCR and/or virus isolation of acute samples. D = DENV.dPrevious infecting serotypes were determined based on the neutralization pattern, the epidemiology of dominant DENV serotype circulation in Nicaragua, and the age of patients [29]. Asterisks indicate the highest NT50, which suggests the previous infecting serotypes consistent with the epidemiological history.eNT50 was determined as described in Methods.f[anti-FL Abs] was determined as described in Methods.gPrevious infecting serotype(s) could not be determined.