The idenfication and the tumorigenesis mechanism study of the acutely tranforming virus strain FAFU01

It was known that the acutely transforming strain of retrovirus can induce theacute transformation in chicken embryo fibroblast (CEF).A strain of virus wasisolated from the clinicial tumor tissue of some broiler breeder. It was foundthat this virus isolate acutely transformed CEF in vitro and incubation of thisisolate in the chicken embryos could induce the hemangioma on the bodysurface.However the ELISA test of the group-specific antigen, p27, and specificPCR test for different subgroups ALSV showed both negative results. It can beconcluded that the pathogen is some unknown virus. We plan to reveal the etiologycharacter including the morphological structure, physicochemical characteristicsand the tumorigenesis peculiarity, as well as the the tumorigenesis mechanism ofthe virus, in order to explain the molecular mechanism of acute transformation ofthe isolate and to provide the basis of the clinical prevention and control of thespread of the associated acute phymatosis.