Rational Modification of Human Gut Microbial Metabolites by Dietary Resistant Starch in Patients After Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective Feasibility Study

We conducted a prospective longitudinal feasibility study in patients undergoing allo-HCT for hematological malignancies to test the hypothesis that defined and consistent administration of resistant starch will rationally modify intestinal microbiota dependent metabolites, particularly the short chain fatty acids (SCFA), such as butyrate. Ten adults undergoing human leukocyte antigen-matched, related-donor myeloablative allo-HCT were enrolled and received resistant potato starch (RPS) daily from day -7 to day 100 after allo-HCT.本研究针对罹患血液系统恶性肿瘤、接受异基因造血干细胞移植（allo-HCT）的患者开展前瞻性纵向可行性研究，旨在验证下述假说：规范且持续地给予抗性淀粉，可合理调控肠道菌群依赖性代谢产物，尤其是短链脂肪酸（SCFA）如丁酸的水平。本研究共纳入10例接受人类白细胞抗原配型相合亲缘供者清髓性异基因造血干细胞移植的成人患者，受试者于异基因造血干细胞移植前第7天至移植后第100天每日服用抗性马铃薯淀粉（RPS）。