Median ages and age ranges for cancer in Werner syndrome versus other cancer predisposition syndromes.

*malignant cases only, except for meningiomas where benign cases were also included. **Japan-residents cases only, excluding tumor cases with ambiguous age at diagnosis. ***BS = Bloom syndrome. Some discrepancies between data given in Figure 2 and Table 4 of reference [23]. ****RTS = Rothmund-Thomson syndrome [25]. Note that adding 6 additional tumor cases reported in patients with RAPADILINO syndrome, which is also caused by mutations in RecQL4, has minimal effect (all sites estimate becomes 13 (2, 33)). *****Osaka population ages given by 5-year age groups, so medians are approximate. Data obtained from CI5plus online application (years 1963–2002); soft tissue and all sites data from CI5 volumes 3–9 (years 1970–2002) [7]. SEER data from [35]. na = not accessed.