Single cell DNA sequencing of the zebrafish superficial epithelial cells

We discovered that the superficial epithelial cells (SECs) of zebrafish larvae could adapt a unique kind of cell division during rapid growth conditions. We termed it "asynthetic fission". We determined that asynthetic fission occurs in the absence of DNA replication, generating progeny cells with reduced genome size. Here, we aim to define the genomic landscape of the SECs during asynthetic fission by applying single-cell DNA sequencing using the Tapestri platform (Mission Bio).