DNA polymerase β (pol β) is a 39-kDa protein that functions in DNA repair processes in mammalian cells. As a first step toward understanding mechanisms of polymerase fidelity, we developed a genetic m
The evolution and host adaptation of influenza viruses are facilitated by the highly error-prone replication process catalyzed by the viral RNA-dependent RNA polymerase. However, amino acid residues
CCA-adding enzymes are highly specific RNA polymerases that synthesize and maintain the sequence CCA at the tRNA 3‘-end. Here, we investigated the impact of cold adaptation on the reactivity and speci
aNumber of mutations per 650 bases (KlenTaq wild-type) or 726 bases (R660V) sequenced per clone.bError rate equals number of mutations per base per division.cData taken from [63].
Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*(DOC)-3')
