Regulatory profiles of WT and REST-Tg mouse CGNPs

RE1 Silencing Transcription Factor (REST) is a repressor of transcriptional initiation of genes involved in neurogenesis. Here, we conditionally elevate REST expression in cerebellar granule cell progenitors (CGNPs) of REST-Tg mice and conduct transcriptome-wide analysis of RNA expression (RNA-seq), chromatin accessibility (ATAC-seq), and epigenetic histone modification profiles (ChIP-seq). Preprint available at: https://doi.org/10.1101/2025.10.15.682654.RE1沉默转录因子（RE1 Silencing Transcription Factor，REST）是参与神经发生的基因转录起始的抑制因子。本研究在REST转基因（REST-Tg）小鼠的小脑颗粒细胞祖细胞（CGNPs）中条件性升高REST的表达，并对RNA表达（RNA测序，RNA-seq）、染色质可及性（转座酶可及性测序，ATAC-seq）以及表观遗传组蛋白修饰谱（染色质免疫共沉淀测序，ChIP-seq）开展全转录组分析。本研究的预印本可在以下链接获取：https://doi.org/10.1101/2025.10.15.682654.