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Hydroxyalkylation-Initiated Radical Cyclization of N‑Allylbenzamide for Direct Construction of Isoquinolinone

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Figshare2016-02-13 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Hydroxyalkylation_Initiated_Radical_Cyclization_of_i_N_i_Allylbenzamide_for_Direct_Construction_of_Isoquinolinone/2161213
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A metal-free hydroxyalkylation-initiated radical six-membered heterocycle formation reaction of N-allylbenzamide is developed. This reaction proceeds through C­(sp3)–H bond cleavage, oxyalkylation of the double bond, and intramolecular cyclization, which provides a new route toward 4-substituted 3,4-dihydroisoquinolin-1­(2H)-one derivatives.
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2016-02-13
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