MODERN THERAPEUTIC APPROACHES TO UNSTABLE ANGINA

Unstable angina (UA) represents a critical phase of ischemic heart disease, necessitating rapid risk stratification and intervention to prevent myocardial infarction. This article presents a prospective clinical study conducted at the Department of Faculty Therapy of Andijan State Medical Institute. Utilizing the IMRAD framework, the research evaluates the efficacy of an "Early Invasive Strategy" (coronary angiography within 24 hours) compared to an "Optimized Conservative Strategy" (medical therapy with selective angiography) in 120 high-risk UA patients. The study also integrates a novel assessment of metabolic and neurohumoral markers. Results indicate that the early invasive approach significantly reduces the incidence of Major Adverse Cardiovascular Events (MACE) at 6 months (15 percent vs. 32 percent). Furthermore, the study highlights the importance of correcting lipid peroxidation and sympathetic overactivity as adjunct therapeutic targets. The authors conclude that while revascularization is crucial, long-term prognosis depends on a holistic approach combining interventional cardiology with targeted metabolic therapy.

不稳定型心绞痛（Unstable angina，UA）是缺血性心脏病的危急阶段，需快速开展危险分层与干预以预防心肌梗死。本研究为在安集延国立医学院治疗学系开展的前瞻性临床研究，采用IMRAD研究框架。研究纳入120例高危UA患者，对比了“早期侵入性策略”（24小时内完成冠状动脉造影）与“优化保守治疗策略”（联合选择性造影的药物治疗）的临床疗效，并新增了代谢及神经体液标志物的评估维度。结果显示，早期侵入性策略可显著降低6个月随访时的主要不良心血管事件（Major Adverse Cardiovascular Events，MACE）发生率（15% vs. 32%）。此外，本研究强调了校正脂质过氧化与交感神经过度激活作为辅助治疗靶点的重要性。研究团队最终得出结论：尽管血管重建术至关重要，但长期预后需依托结合介入心脏病学与靶向代谢治疗的综合诊疗方案。