Myeloid cell METTL1 deletion significantly mitigated CLP-induced multiple organ injury and I/ R-induced kidney injury

1. METTL1 expression was upregulated in monocytes/macrophages during acute inflammation2. Myeloid METTL1 depletion alleviated tissue damage induced by CLP and I/R3. METTL1 promoted infiltration and pro-inflammatory differentiation of macrophages4. SARM1-induced NAD+ consumption is crucial for the METTL1-induced metabolic reprogramming of macrophages5. SA91-0178, a METTL1 inhibitor, effectively alleviated injuries induced by CLP and I/R