siRNAOD3

This repository contains siRNAOD3, the largest multi-modal siRNA database currently available, comprising 63,113 rigorously curated entries. The dataset integrates heterogeneous molecular, chemical, and experimental metadata to support siRNA design, efficacy prediction, mechanism studies, and benchmarking of computational models. Dataset Contents:1. Bare sequences: Unmodified sense and antisense strand sequences for each siRNA duplex.2. Chemically modified sequences: Detailed records of backbone, sugar, base, and terminal modifications applied to each strand.3. Experimental conditions: Cell lines types, delivery methods, transfection concentrations, incubation times, and quantitative silencing measurements.4. Target gene sequences: Corresponding mRNA sequences. The manuscript describing the siRNAOD3 is currently under peer review. This dataset is released on Zenodo to support reproducibility and preliminary research. Upon acceptance and formal publication, this record will be fully open access under a permanent license for unrestricted download, reuse, and citation. In the meantime, please cite this Zenodo record when using the dataset in your work. Complete citation metadata will be updated upon publication.For inquiries, data validation requests, or collaboration: [e-mail], [e-mail].本仓库收录了当前已公开的规模最大的多模态小干扰RNA（small interfering RNA，siRNA）数据库siRNAOD3，共计63113条经过严格人工筛选整理的条目。该数据集整合了异质性的分子、化学与实验元数据，可用于支撑小干扰RNA的设计、效力预测、机制研究以及计算模型的基准测试工作。 数据集内容如下： 1. 未修饰序列：每条siRNA双链的正义链与反义链序列。 2. 化学修饰序列：每条链所经历的骨架、糖基、碱基与末端修饰的详细记录。 3. 实验条件：细胞系类型、递送方式、转染浓度、孵育时长以及定量沉默效应检测数据。 4. 靶基因序列：对应的信使RNA（messenger RNA，mRNA）序列。 描述siRNAOD3的研究论文目前正处于同行评审阶段。本数据集已在Zenodo平台发布，以支持研究的可重复性与前期探索工作。待论文被接收并正式发表后，本数据集将通过永久许可协议完全开放获取，支持无限制的下载、复用与引用。在此期间，若您在研究中使用本数据集，请引用该Zenodo记录；完整的引用元数据将在论文发表后更新。 若有咨询、数据验证申请或合作意向，请联系：[e-mail]、[e-mail]。