Endocytosis of clathrin-coated vesicle

Dynamin is a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. It is involved in vesicle trafficking processes and is necessary for endocytosis.
Dynamins are large GTPases that bind to PIP2-containing membranes, several SH3-domain containing proteins and cytoskeletal modifiers. They self-polymerize in a GTP dependent manner, catalyzing the scission of invaginating membranes during endocytosis (Praefcke & McMahon, 2004).
There are three dynamins in humans: dynamin I is neuron-specific; dynamin II shows ubiquitous expression; dynamin III is expressed in testis, brain, lung and blood platelets.

Dynamins，作为一种与微管相结合、负责产生微管束并能够结合及水解GTP的微管相关力生成蛋白，参与囊泡运输过程，对于内吞作用至关重要。这些大型的GTP酶与含有PIP2的膜、多个含SH3结构域的蛋白以及细胞骨架调节因子结合。它们在GTP依赖性方式下自我聚合，催化内吞过程中内陷膜的裂解（Praefcke & McMahon，2004）。人类中共有三种Dynamins：Dynamins I具有神经元特异性；Dynamins II呈现普遍表达；Dynamins III则在睾丸、大脑、肺以及血液血小板中表达。