The midpoints of inactivation (V1/2) and slope factors (k) were obtained from a single or double Boltzmann fit. Values are means ± S.E.; n, number of experiments; -, not applicable. For comparison, th
Modulation of single-channel parameters of native If (control) by KCR1 overexpression (KCR1-infected) and knock-down of endogenous KCR1 (KCR1siRNA-infected) in adult and neonatal cardiomyocytes. Holdi
= 5–9, *P<0.05, **P<0.01, ***P<0.001). Values were obtained from mean data fitted with the Boltzmann equation. Statistically significant differences were determined with a one-way ANOVA test followed
Whole-cell patch-clamp recordings of membrane currents and Fura-2 measurements of free intracellular calcium concentration ([Ca2+]i) were used to study calcium influx through receptor-activated cation
