Crystal structure of human c-KIT kinase domain in complex with AZD3229-analogue (compound 35)

Crystal structure of human c-KIT kinase domain in complex with AZD3229-analogue (compound 35) Descriptor: Mast/stem cell growth factor receptor Kit, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide Authors: Schimpl, M, Hardy, C.J, Ogg, D.J, Overman, R.C, Packer, M.J, Kettle, J.G, Anjum, R, Barry, E, Bhavsar, D, Brown, C, Campbell, A, Goldberg, K, Grondine, M, Guichard, S, Hunt, T, Jones, O, Li, X, Moleva, O, Pearson, S, Shao, W, Smith, A, Smith, J, Stead, D, Stokes, S, Tucker, M, Ye, Y. Deposit date: 2018-06-07 Release date: 2018-09-19 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors. J. Med. Chem., 61, 2018

人源c-KIT激酶结构域与AZD3229类似物（化合物35）结合的晶体结构
标识：肥大细胞/干细胞生长因子受体Kit，~N-[4-(6,7-二甲氧基喹唑啉-4-基)氧苯基]-2-(4-异丙基-1,2,3-三唑-1-基)乙酰胺
作者：Schimpl, M; Hardy, C.J; Ogg, D.J; Overman, R.C; Packer, M.J; Kettle, J.G; Anjum, R; Barry, E; Bhavsar, D; Brown, C; Campbell, A; Goldberg, K; Grondine, M; Guichard, S; Hunt, T; Jones, O; Li, X; Moleva, O; Pearson, S; Shao, W; Smith, A; Smith, J; Stead, D; Stokes, S; Tucker, M; Ye, Y.
入库日期：2018年6月7日
发布日期：2018年9月19日
最后修改日期：2024年5月15日
检测方法：X射线衍射（分辨率2.01 Å）
引用文献：《N-(4-{[5-氟-7-(2-甲氧基乙氧基)喹唑啉-4-基]氨基}苯基)-2-[4-(异丙基)-1H-1,2,3-三唑-1-基]乙酰胺（AZD3229）：一种用于治疗胃肠道间质瘤的强效泛KIT突变体抑制剂》，《药物化学杂志》，第61卷，2018年