miR-214 microRNA binds PTEN mRNA

MicroRNA miR-214-3p, one of the two mature products of miR-214, binds to the 3'UTR of the PTEN mRNA and inhibits PTEN mRNA translation. As miR-214 reduces PTEN protein levels but not PTEN mRNA levels, miR-214 presumably functions as part of the nonendonucleolytic RISC. miR-214 is frequently overexpressed in ovarian cancer (Yang et al. 2008).

MicroRNA miR-214-3p，作为miR-214的两个成熟产物之一，与PTEN mRNA的3'非编码区（3'UTR）结合，从而抑制PTEN mRNA的翻译。由于miR-214降低PTEN蛋白水平而非PTEN mRNA水平，推测miR-214可能作为非末端核酸酶活性RISC的一部分发挥作用。miR-214在卵巢癌中常呈现过表达状态（见Yang等，2008年）。