Clinical characteristics1 of German cohort.

1Family history was unknown for 54 cases with ASDII and 37 cases with PFO. Other Clinical characteristics were unknown for a small number of patients.2All ASDII cases were free of any other cardiac malformation.3All PFO cases were free of any other cardiac malformation. All were designated as having cryptogenic stroke.4Neurologic event includes thromboembolic stroke, PRIND (prolonged reversible ischemic neurologic deficit) and TIA.5Defect closure includes interventional closure and surgical closure.6AVB: electrocardiographic atrioventricular block.7iRSB/RSB: (incomplete) right bundle block.