Effect of selenium supplementation on changes in plasma adiponectin and selenium concentrations after six months*

*Results were obtained from linear mixed models on log-transformed adiponectin levels (and untransformed selenium levels) with fixed treatment-by-time interactions and random between-subject variations in both baseline levels (intercepts) and longitudinal changes over time (slopes).†P values comparing the ratio of geometric mean adiponectin levels (and the change in arithmetic mean selenium levels) at six months to baseline in each active treatment group to placebo, as obtained from Wald tests for each treatment-by-time interaction coefficient in linear mixed models.‡Overall P value comparing the three active treatment groups to placebo, as obtained from the joint Wald test for all treatment-by-time interaction coefficients in linear mixed models.