Endocrine profile of the vcd-induced perimenopausal model rat

During the transition to menopause, women experience a variety of physical and psychological symptoms that are directly or indirectly linked to changes in hormone secretion. Establishing animal models with intact ovaries is essential for understanding these interactions and finding new therapeutic targets. In this study, we assessed the endocrine profile, as well as the estrous cycle, in the 4-vinylcyclohexene diepoxide (VCD)-induced follicular depletion rat model in 10-day intervals over 1 month to accurately establish the best period for studies of the transition period.女性在围绝经期阶段会出现多种躯体与心理症状，这些症状与激素分泌变化存在直接或间接关联。构建保留完整卵巢的动物模型，是阐明此类生理交互机制、发掘全新治疗靶点的关键前提。本研究以4-乙烯基环己烯二环氧化物（4-vinylcyclohexene diepoxide, VCD）诱导的卵泡耗竭大鼠模型为研究对象，在为期1个月的周期内以每10天为间隔，对其内分泌谱与动情周期进行系统评估，以期精准确定围绝经期相关研究的最优周期时长。