Gene expression profiling of human fibroblast MRC5 cells exposed to cigarette smoke condensate (CSC)

Smoking is the main risk factor for many lung diseases including chronic obstructive pulmonary disease. Cigarette smoke (CS) contains carcinogenic and reactive oxygen species that favor DNA mutations and perturb the homeostasis and environment of cells. CS induces lung cell senescence resulting in a stable proliferation arrest and a senescence-associated secretory phenotype. It was recently reported that senescent cell accumulation promotes several lung diseases. Normal human fibroblast cells (MRC5) were cultured with or without Cigarette Smoke Condensate