Stable and dynamic representations of value in the prefrontal cortex

Monkeys were first trained a value based decision making task in which a cue predicted a delayed reward. A detailed explanation of the task and first analysis of the data with decision trials can be found in Rich, E. L., & Wallis, J. D. (2016). Decoding subjective decisions from orbitofrontal cortex. Nature Neuroscience, 19(7), 973–980 10.1038/nn.4320. This data set only contains the data of single cue in which the animal was looking at a reward predicting cue, performed an unrelated joystick reponse task during a delay, and received the reward associated with the cue. Monkeys were head fixed, while single electrodes were lowered in the OFC (areas 11 and 13) and the dorsal bank of the ACC sulcus (area 24). All well isolated neurons were recorded without discrimination. Neurons were filtered out if there firing rate over the session was lower than 1Hz. This data set contains both single and multi units without distinction. The firing rate was estimated either with gaussian or square window, and with different parameters: - type of smoothing: either gaussian or square - the size of the smoothing window: either 100ms or 50ms - the step between each bin: 25ms, 50ms or 200ms - the alignment of the bins: either center to the original timing or to the end of the bin. When centered to the end of the bin, only data before the timing of the bin is included in the bin. Pseudo-population data sets are generated with a specific seed to match the number of trials in each condition across monkey and recording session.首先对猕猴开展基于价值的决策任务训练，任务中提示线索会预示延迟发放的奖励。该任务的详细说明以及基于决策试次的初始数据分析可参见文献：Rich, E. L. 与 Wallis, J. D. (2016)。《从眶额叶皮层（Orbitofrontal Cortex, OFC）解码主观决策》，《自然神经科学》，19(7)，973–980，DOI: 10.1038/nn.4320。 本数据集仅包含单线索试次的数据：受试动物注视奖励预示线索后，在延迟期内完成一项无关的操纵杆响应任务，最终获得与该线索关联的奖励。 实验中猕猴头部被固定，同时通过单电极分别记录眶额叶皮层（OFC，11区与13区）以及扣带沟背侧的前扣带回皮层（Anterior Cingulate Cortex, ACC，24区）的神经活动。所有分离良好的神经元均被记录，未进行选择性筛选。若神经元在整个实验会话中的平均放电率低于1Hz，则会被过滤排除。本数据集包含单单元与多单元神经活动数据，未做区分。 放电率可通过两种平滑窗口结合不同参数进行估计： - 平滑类型：高斯平滑或矩形平滑 - 平滑窗口大小：100ms或50ms - 相邻时间箱步长：25ms、50ms或200ms - 时间箱对齐方式：以原始时间点为中心，或以时间箱终点为中心。当以时间箱终点对齐时，仅将该时间箱对应时刻之前的数据纳入该箱内。 伪群体数据集通过指定随机种子生成，以匹配不同猕猴个体及各记录会话下各实验条件的试次数量。