Macrophage depletion alters bacterial gut microbiota partly through fungal overgrowth in feces that worsens cecal ligation and puncture sepsis mice

Macrophage depletion causes an ineffective control in balancing gut microbiota, especially gut fungi, that might enhance sepsis severity. As such, cecal ligation and puncture (CLP) surgery was performed on macrophage-depleted mice using fecal microbiome analysis and other several investigations.