Additional file 1: Figure S1. of Quantitative analysis of cryptic splicing associated with TDP-43 depletion

Pre-classification output of CryptEx pipeline demonstrates a variety of novel splicing events in TDP-43, FUS and hnRNP C depletion data. Every novel splicing event plotted by mean depth of reads covering the novel event against log2(fold change) between depletion and control samples. The cryptic exon classifier throws out any splicing event where the canonical intron in which the cryptic splicing event appears is represented by less than five spliced reads (purple) or where the |log2(fold change)| < 0.6 (light blue). Splicing events are classified as cryptic exons if the spliced reads agree with the rest of the reads and have at least 1 spliced read per sample (red). Those that fail this step are coloured orange. (ZIP 1386 kb)