Wee1 inhibition in acute lymphoblastic leukemia with MLL rearrangement.
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE148195
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资源简介：
Enhancer activity and RUNX1 binding was studied using ChIP-seq in mixed lineage leukemia t(4;11) rearranged acute lymphoblastic leukemia upon inhibition of the WEE1 kinase. ChIP-seq profiles were generated from RS4;11 cell line carrying the MLL rearrangment t(4;11) after 24 h WEE1 inhibition by AZD1775. DMSO treated cells were used as controls. Brief sonication followed by Mnase digestion was used for DNA fragmentation. ChIP lysates were prepared with antibodies against H3K27ac and RUNX1 and compared to input.
创建时间：
2024-06-26
