Metadata record for the article: Next-generation sequencing revealed recurrent ZFPM1 mutations in encapsulated papillary carcinoma of the breast

Summary

This
metadata record provides details of the data supporting the claims of the
related article: “Next-generation sequencing revealed
recurrent ZFPM1 mutations in encapsulated papillary carcinoma of the breast”.

The
related study aimed to gain further insight into encapsulated papillary
carcinoma (EPC) mutation profile.

Type of data:
whole exome sequencing; gene targeted sequencing

Subject of
data: Homo sapiens

Population
characteristics: patients had been diagnosed with encapsulated papillary
carcinoma of the breast

Recruitment:
EPCs diagnosed from 2015 to 2018 were retrospectively retrieved from the
surgical pathology files, then patients were contacted by phone and email.

Data
access

The raw sequencing
data are openly available in the NCBI Sequence
Read Archive, and can be accessed via the following BioProject accession: https://identifiers.org/bioproject:PRJNA685582. These data have also been deposited in the Genome Sequence Archive (Genomics, Proteomics & Bioinformatics
2017) in the National Genomics Data Center (Nucleic Acids Res 2020), Beijing
Institute of Genomics (China National Center for Bioinformation), Chinese
Academy of Sciences. The accession code is HRA000480.

The TCGA dataset used in the related article
is from https://tcga-data.nci.nih.gov/docs/publications/brca_2012/
.

Additional
data underlying the figures of the related article are openly available in the
files included with this figshare data
record. Details of these files are as follows:

- Supplementary
Data 1: The clinicopathologica information and feature of 41 EPCs.

- Supplementary
Data 2: Somatic mutations detected by whole-exome sequencing in 26 EPCs

- Supplementary
Data 3: Somatic mutations detected by targeted sequencing in 41 EPCs

- Supplementary
Data 4: ZFPM1 mutations in breast cancer from COSMIC datesets.

- Supplementary
Table 3 and Supplementary Figure 4 were included in the Supplementary Information
file.

Corresponding author(s) for this study

Zhiyong
Liang, Department of Pathology, Peking Union Medical College Hospital,
Molecular Pathology Research Center, Chinese Academy of Medical Sciences and
Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District,
Beijing, China 100730, [e-mail]

Study
approval

The
study protocol was approved by the Ethical Committee of Peking Union Medical
University Hospital.