Dataset on the effect of vancomycin on metabolic changes in type 1 diabetic mice

Here we treated streptozotocin-induced diabetic mice with vancomycin (Vanc) to disturb the gut microbiota and host metabolic phenotype. In order to study the effect of vancomycin on host metabolism, a 1H NMR-based metabolomics approach was applied to analyze metabolic changes in caecum contents, feces, caecum tissues, colonic tissues, serum, and hippocampus of normal control (CON), type 1 diabetic (T1D), and vancomycin-treated type 1 diabetic (T1DV) mice at 3, 7 and 11 weeks. This study is submitted to Microbiome. Hong Zheng, Pengtao Xu, Qiaoying Jiang, Qingqing Xu, Yafei Zheng, Junjie Yan, Hui Ji, Jie Ning1, Xi Zhang, Chen Li, Limin Zhang, Yuping Li, Xiaokui Li, Weihong Song, and Hongchang Gao. (2021). Depletion of acetate-producing bacteria from the gut microbiota facilitates cognitive impairment through the gut-brain neural mechanism in diabetic mice.