NEUROVASCULAR AND INFLAMMATORY MECHANISMS OF MIGRAINE: CLINICAL FEATURES AND MODERN DIAGNOSTIC APPROACHES

Migraine is one of the most common neurological disorders characterized by recurrent headache attacks and significant impairment of quality of life. Modern studies indicate that neurovascular dysfunction, inflammatory activation, and neurotransmitter imbalance play central roles in migraine pathogenesis. The aim of this study was to evaluate the clinical, inflammatory, and neurovascular characteristics of migraine and determine the significance of laboratory and neurological markers in disease severity. The study included 52 patients with clinically diagnosed migraine who underwent neurological and laboratory evaluation. Elevated inflammatory markers, autonomic dysfunction, and increased attack frequency were significantly associated with severe migraine manifestations. Statistical analysis demonstrated a strong positive correlation between C-reactive protein levels and migraine attack frequency (r = 0.71; p <0.001). The findings confirm the importance of inflammatory and neurovascular mechanisms in migraine progression and emphasize the role of early diagnosis in preventing chronic complications.偏头痛是最为常见的神经系统疾病之一，以反复发作性头痛及显著的生活质量受损为核心临床特征。现代研究证实，神经血管功能障碍、炎症激活与神经递质失衡在偏头痛发病机制中占据核心地位。本研究旨在评估偏头痛的临床、炎症及神经血管特征，并明确实验室与神经系统标志物在疾病严重程度评估中的应用价值。本研究共纳入52例经临床确诊的偏头痛患者，所有受试者均接受了神经系统检查与实验室检测评估。炎症标志物水平升高、自主神经功能障碍以及发作频率增加，与严重偏头痛临床表现呈显著相关性。统计学分析显示，C反应蛋白（C-reactive protein）水平与偏头痛发作频率存在极强的正相关关系（r = 0.71; p < 0.001）。本研究结果证实了炎症与神经血管机制在偏头痛进展中的重要性，并强调了早期诊断对于预防慢性并发症的关键作用。