Dataset related to:"Prenylcysteine oxidase 1, an emerging player in atherosclerosis "

This record contains raw data related to the article " Prenylcysteine oxidase 1, an emerging player in atherosclerosis" Abstract The research into the pathophysiology of atherosclerosis has considerably increased our understanding of the disease complexity, but still many questions remain unanswered, both mechanistically and pharmacologically. Here, we provided evidence that the pro-oxidant enzyme Prenylcysteine Oxidase 1 (PCYOX1), in the human atherosclerotic lesions, is both synthesized locally and transported within the subintimal space by proatherogenic lipoproteins accumulating in the arterial wall during atherogenesis. Further, Pcyox1 deficiency in Apoe^-/- mice retards atheroprogression, is associated with decreased features of lesion vulnerability and lower levels of lipid peroxidation, reduces plasma lipid levels and inflammation. PCYOX1 silencing <em>in vitro </em>affects the cellular proteome by influencing multiple functions related to inflammation, oxidative stress, and platelet adhesion. Collectively, these findings identify the pro-oxidant enzyme PCYOX1 as an emerging player in atherogenesis and, therefore, understanding the biology and mechanisms of all functions of this unique enzyme is likely to provide additional therapeutic opportunities in addressing atherosclerosis.本数据集包含与论文《异戊烯半胱氨酸氧化酶1：动脉粥样硬化中的新兴调控因子》相关的原始数据。 摘要：针对动脉粥样硬化病理生理学的研究已大幅提升了我们对该疾病复杂性的认知，但在机制层面与药理学层面仍有诸多问题尚未得到解答。本研究证实，促氧化酶异戊烯半胱氨酸氧化酶1（Prenylcysteine Oxidase 1，PCYOX1）在人类动脉粥样硬化病灶中可局部合成，并可通过动脉粥样硬化发生过程中在动脉壁内蓄积的致动脉粥样硬化脂蛋白转运至内膜下层间隙。此外，在载脂蛋白E基因敲除（Apoe^-/-）小鼠中，Pcyox1基因缺陷可延缓动脉粥样硬化进展，与病灶易损性特征降低、脂质过氧化水平下降相关，同时可降低血浆脂质水平与炎症反应。体外（in vitro）实验中，PCYOX1基因沉默可通过影响炎症、氧化应激与血小板黏附相关的多种生物学功能，改变细胞蛋白质组。综上，本研究结果将促氧化酶PCYOX1确定为动脉粥样硬化发生过程中的新兴调控因子，因此，阐明这一独特酶类所有功能的生物学特性与作用机制，有望为动脉粥样硬化的治疗提供全新的治疗靶点与策略。