Single Cell Transcriptional and Chromatin Accessibility Profiling on the human adult kidneys with autosomal dominant polycystic kidney disease. Single Cell Transcriptional and Chromatin Accessibility Profiling on the human adult kidneys with autosomal dominant polycystic kidney disease

We performed single nucleus ATAC (snATAC-seq) and RNA (snRNA-seq) sequencing to generate paired, cell-type-specific chromatin accessibility and transcriptional profiles of the adult human kidney with autosomal dominant polycystic kidney disease. snATAC-seq on 5 samples (control1/2/3/4/5) were already done and deposited on GSE151302 as Healthy1-5 (GSM4572187-4572191, respectively) Overall design: n=8 ADPKD and n=5 control human adult kidney cortex samples were analyzed with snRNA-seq and snATAC-seq (10xGenomics platform). snATAC-seq sequencing of 5 samples (control1/2/3/4/5).