Study of a mouse model of angioimmunoblastic T-cell lymphoma

Angioimmunoblastic T-cell lymphoma (AITL) is proposed to be initiated by age-related clonal hematopoiesis (ACH) with TET2 mutations, whereas the G17V RHOA mutation in immature cells with TET2 mutations promotes development of T follicular helper-like tumor cells. Here, we investigated the mechanism by which TET2-mutant immune cells enable AITL development, using mouse models and human samples. Single-cell RNA-sequencing revealed significant expansion of aberrant B cells. The GCB cells in AITL clonally evolved with recurrent mutations.