Dataset related to article "Selective antitumor activity of Tumor Treating Fields (TTFields) involving molecular factors in cancer cells and tumor microenvironment"

This record contains data related to article “Selective antitumor activity of Tumor Treating Fields (TTFields) involving molecular factors in cancer cells and tumor microenvironment”. The local application of low-intensity electric fields at intermediate frequencies (Tumor Treating Fields – TTFields) has emerged as an effective anticancer treatment in conjunction with chemotherapy and immunotherapy for several solid tumors. Despite this progress, the phenotypic and genetic determinants underlying tumor sensitivity to TTFields remain largely unexplored, representing a critical gap in our understanding. This review provides a comprehensive analysis of preclinical and translational studies describing the cellular factors that influence the anticancer properties of TTFields. An overview of recent omics studies on the complex cellular and molecular processes initiated by TTFields has revealed important mechanisms of action that warrant further investigation for their therapeutic potential. The goal is to identify effects that can be leveraged to develop rational, synergistic co-treatments with anticancer agents that have complementary modes of action. In particular, the ability of TTFields to modulate the tumor microenvironment and reverse the local and systemic immunosuppression could represent a promising strategy to enhance the efficacy of immunotherapy across different tumor types.本数据集收录与题为《肿瘤治疗电场（Tumor Treating Fields, TTFields）的选择性抗肿瘤活性：涉及癌细胞与肿瘤微环境的分子因素》的学术论文相关的数据。 中频低强度电场的局部应用（即肿瘤治疗电场（Tumor Treating Fields, TTFields））现已成为多种实体肿瘤联合化疗与免疫治疗的有效抗肿瘤手段。尽管该领域已取得上述进展，但肿瘤对TTFields产生敏感性的表型与遗传决定因素仍未得到充分探索，这是当前研究认知中的关键空白。 本综述对探讨影响TTFields抗肿瘤特性的细胞因素的临床前与转化研究进行了全面梳理。针对TTFields所引发的复杂细胞与分子过程的最新组学（omics）研究综述显示，其潜在治疗价值相关的重要作用机制有待进一步深入研究。 本研究旨在识别可被利用的效应机制，以开发与作用机制互补的抗肿瘤药物进行合理的协同联合治疗。尤为重要的是，TTFields能够调节肿瘤微环境并逆转局部与全身性免疫抑制，这或可成为提升不同肿瘤类型免疫治疗疗效的极具前景的策略。