Patient-derived brain organoids uncover reversible cellular abnormalities in Pitt-Hopkins Syndrome III. Patient-derived brain organoids uncover reversible cellular abnormalities in Pitt-Hopkins Syndrome III
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA670694
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资源简介:
We evaluate cellular phenotypic abnormalities and alterations in molecular pathways due to mutations in the gene TCF4 in cells derived from Pitt-Hopkins patients, in comparison with respective controls (parents). Overall design: Comparison between single cell RNA-Seq libraries of brain organoids derived from Pitt-Hopkins Syndrome patients and respective parents of matching sex.
创建时间:
2020-10-22



