IMC Diabetes dataset (Damond et al.)

The IMC dataset generated by Damond et al. longitudinally profiles pancreatic tissue samples obtained from 67 human donors, including both non-diabetic individuals and patients diagnosed with Type 1 diabetes (T1D). The dataset is comprised of 33 non-diabetic controls and 34 donors with established long-standing T1D. Long-standing T1D represents patients with prolonged disease duration following diagnosis, typically characterized by sustained autoimmune-mediated β-cell depletion and chronic inflammatory remodeling of the pancreatic microenvironment. The IMC panel stained for 38 proteins.由Damond等人构建的成像质谱流式（Imaging Mass Cytometry, IMC）数据集，对67名人类供体的胰腺组织样本开展了纵向表征，样本覆盖非糖尿病个体与确诊1型糖尿病（Type 1 Diabetes, T1D）患者。该数据集包含33例非糖尿病对照样本与34例确诊为长期患病的1型糖尿病供体样本。长期1型糖尿病指确诊后病程迁延的患者群体，其典型特征为自身免疫持续介导的胰岛β细胞耗竭，以及胰腺微环境的慢性炎症重塑。本次IMC检测的抗体组合针对38种蛋白质完成了染色标记。