Data from: Genetic determinants for gestational diabetes mellitus and related metabolic traits in Mexican women

Epidemiological and physiological similarities among Gestational Diabetes
Mellitus (GDM) and Type 2 Diabetes (T2D) suggest that both diseases, share
a common genetic background. T2D risk variants have been associated to GDM
susceptibility. However, the genetic architecture of GDM is not yet
completely understood. We analyzed 176 SNPs for 115 loci previously
associated to T2D, GDM and body mass index (BMI), as well as a set of 118
Ancestry Informative Markers (AIMs), in 750 pregnant Mexican women.
Association with GDM was found for two of the most frequently replicated
T2D loci: a TCF7L2 haplotype (CTTC: rs7901695, rs4506565, rs7903146,
rs12243326; P=2.16x10-06; OR=2.95) and a KCNQ1 haplotype (TTT: rs2237892,
rs163184, rs2237897; P=1.98x10-05; OR=0.55). In addition, we found two
loci associated to glycemic traits: CENTD2 (60’ OGTT glycemia: rs1552224,
P=0.03727) and MTNR1B (HOMA B: rs1387153, P=0.05358). Remarkably, a major
susceptibility SLC16A11 locus for T2D in Mexicans was not shown to play a
role in GDM risk. The fact that two of the main T2D associated loci also
contribute to the risk of developing GDM in Mexicans, confirm that both
diseases share a common genetic background. However, lack of association
with a Native American contribution T2D risk haplotype, SLC16A11, suggests
that other genetic mechanisms may be in play for GDM.