DOES POLYCYSTIC OVARY SYNDROME IMPACT THE MORPHOKINETICS OF BLASTOCYST DEVELOPMENT? A TIME–LAPSE–BASED ANALYSIS

297 zygotes from PCOS patients and 259 zygotes from non-PCOS patients without PCOS were observed and followed up. Embryos from the PCOS patient group had statistically significant differences in t9, tSB, tEB, and tBSC versus embryos from the control group (69.68 hpi, 108.53 hpi, 110.27 hpi, 111.87 hpi, and 8.53 hrs versus 72.47 hpi, 105.43 hpi, 107.08 hpi, 108.77 hpi, and 7.2 hrs, respectively). The waist circumference ≥ 80 cm in the PCOS group significantly influenced the morphokinetics of the embryo after compaction, with shorter events tM, tSC, and tSB, but longer intervals tBSC, tESC, and tHSC, compared to the non-PCOS group

本研究共纳入297枚取自多囊卵巢综合征（Polycystic Ovary Syndrome, PCOS）患者的受精卵，以及259枚取自非多囊卵巢综合征对照受试者的受精卵，对所有样本开展观察并完成随访。多囊卵巢综合征患者组的胚胎与对照组胚胎在t9、tSB、tEB及tBSC等形态动力学参数上存在具有统计学意义的显著差异；两组对应参数值分别为：PCOS组69.68 hpi、108.53 hpi、110.27 hpi、111.87 hpi及8.53小时，对照组则为72.47 hpi、105.43 hpi、107.08 hpi、108.77 hpi及7.2小时。此外，多囊卵巢综合征组中腰围≥80cm的受试者，其胚胎致密化后的形态动力学特征受到显著影响：与非多囊卵巢综合征组相比，该亚组胚胎的tM、tSC及tSB等发育事件时长更短，而tBSC、tESC及tHSC等间期时长则更长。