Crystal structure of KPC-44 carbapenemase complexed with avibactam
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Crystal structure of KPC-44 carbapenemase complexed with avibactam Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 1,2-ETHANEDIOL, PHOSPHATE ION, ... Authors: Sun, Z, Palzkill, T, Hu, L, Lin, H, Sankaran, B, Wang, J, Prasad, B. Deposit date: 2023-07-30 Release date: 2023-12-06 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J.Biol.Chem., 300, 2023
与阿维巴坦（avibactam）结合的KPC-44碳青霉烯酶晶体结构 配体描述：(2S,5R)-1-甲酰基-5-[(磺氧基)氨基]哌啶-2-甲酰胺、1,2-乙二醇、磷酸根离子…… 作者：Sun, Z, Palzkill, T, Hu, L, Lin, H, Sankaran, B, Wang, J, Prasad, B. 提交日期：2023-07-30 发布日期：2023-12-06 最后修改日期：2024-11-13 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.37埃 引用文献：肺炎克雷伯菌碳青霉烯酶变体44通过改变活性位点环构象获得头孢他啶-阿维巴坦耐药性。J.Biol.Chem., 300, 2023
