Crystal structure of CobB Ac2 (A76G, I131C, V162G) in complex with H4K16Cr-2'OH-ADPr peptide intermediate after co-crystallisation

Crystal structure of CobB Ac2 (A76G, I131C, V162G) in complex with H4K16Cr-2'OH-ADPr peptide intermediate after co-crystallisation Descriptor: Histone H4, NAD-dependent protein deacylase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{S})-4-[(~{E})-but-2-enoxy]-3,5-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate Authors: Spinck, M, Gasper, R, Neumann, H. Deposit date: 2019-06-08 Release date: 2020-04-15 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Evolved, Selective Erasers of Distinct Lysine Acylations. Angew.Chem.Int.Ed.Engl., 59, 2020

共结晶后与H4K16Cr-2'OH-ADPr肽中间体结合的CobB Ac2（A76G、I131C、V162G）晶体结构。描述符：组蛋白H4、烟酰胺腺嘌呤二核苷酸（NAD）依赖性蛋白脱酰基酶，[[(2R,3S,4R,5R)-5-(6-氨基嘌呤-9-基)-3,4-二羟基四氢呋喃-2-基]甲氧基氧代磷酰基] [(2R,3R,4R,5S)-4-[(E)-2-丁烯氧基]-3,5-二羟基四氢呋喃-2-基]甲基氢磷酸酯。作者：Spinck, M、Gasper, R、Neumann, H。存档日期：2019-06-08；发布日期：2020-04-15；最后修改日期：2024-11-13。实验方法：X射线衍射（1.7 Å）。引用文献：《靶向不同赖氨酸酰化的进化选择性擦除剂》，《德国应用化学（国际英文版）》，59卷，2020年。