Comprehensive bioinformatics analysis reveals the hub genes and pathways in a mouse model of Pierpont Syndrome

Unravelling molecular defects resulting from the missense mutation in TBL1XR1 using targeted mutant mice bearing the Tbl1xr1 Y446C/Y446C mutation. These mice used as an animal model of Pierpont syndrome have disturbed hearing and a trend for disturbed locomotor activity. RNA seq of cortex tissue has been performed to establish the transcriptome. Overall design: mRNA profiles for cortex of wild type and Tbl1xr1Y446C/Y446C mice (6 mice for each genotype, 3 male and 3 female mice per genotype).