Digital-array haplotyping: Test for accuracy of the approach in a family study.

Individuals FM1, 2, 3, and 4 were known to be double-heterozygous for the SNP marker pair rs9399137–rs9402685, and phase between the alleles had previously been determined through family relationships (Figure 3). Digital-array haplotyping was carried out in duplicate, with two different probe (i.e., allele) combinations each. All tests arrived at the correct haplotype combination for all for subjects: ‘T-T’ on one chromosome, and ‘C-C’ on its sister chromosome.