Transcriptional profiling of Ewing's sarcoma derived exosomes
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资源简介：
Transcriptional profiling of Ewing's sarcoma derived exosomes
应用场景：
创建时间：
2013-05-01
相关数据集
PRC2 in Ewing tumors
We found the PRC2 component EZH2 to be upregulated by the pathognomonic fusion oncogene EWS-FLI1 in Ewing tumors and mesenchymal stem cells (Richter GH et al., Proc Natl Acad Sci U S A. 2009;106:5324-
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RNA-seq data (STAG2 WT and mutated Ewing sarcoma cell lines)
STAG2 is a member of cohesin complex and its gene is one of the most recurrently mutated in human cancer including in Ewing sarcoma. Here, we investigated STAG2 function in the context of Ewing sarcom
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Transcriptional constraint of EWS/FLI by an ETS transcription factor promotes Ewing sarcoma growth [PEDS0009 CUT&Tag]
Pediatric cancers frequently harbor sentinel mutations involving transcription factors (TFs) that dysregulate normal development. A recurrent mechanism involves the ability of mutant TFs to co-opt cel
NIAID Data Ecosystem40
PRC2 in Ewing tumors. Homo sapiens
We found the PRC2 component EZH2 to be upregulated by the pathognomonic fusion oncogene EWS-FLI1 in Ewing tumors and mesenchymal stem cells (Richter GH et al., Proc Natl Acad Sci U S A. 2009;106:5324-
NIAID Data Ecosystem60
Activation of Wnt/beta-catenin in Ewing sarcoma cells antagonizes EWS/ETS function and promotes phenotypic transition to more metastatic cell states
Ewing sarcomas are characterized by the presence of EWS/ETS fusion genes in the absence of other recurrent genetic alterations and mechanisms of tumor heterogeneity that contribute to disease progress
NIAID Data Ecosystem40
