Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

Knowledge of the full target space of bioactive substances, approved and investigational drugs as well as chemical probes, provides important insights into therapeutic potential and possible adverse effects. The existing compound-target bioactivity data resources are often incomparable due to non-standardized and heterogeneous assay types and variability in endpoint measurements. To extract higher value from the existing and future compound target-profiling data, we implemented an open-data web platform, named Drug Target Commons (DTC), which features tools for crowd-sourced compound-target bioactivity data annotation, standardization, curation, and intra-resource integration. We demonstrate the unique value of DTC with several examples related to both drug discovery and drug repurposing applications and invite researchers to join this community effort to increase the reuse and extension of compound bioactivity data. Citation: Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions Cell Chem Biol. 2018 Feb 15;25(2):224-229.e2. doi: 10.1016/j.chembiol.2017.11.009全面掌握生物活性物质、已获批与在研药物以及化学探针的完整靶标空间，可为阐明其治疗潜力与潜在不良反应提供关键见解。现有化合物-靶标生物活性数据资源往往因检测类型不规范、异质性较强以及终点测量方式存在差异而缺乏可比性。为从现有及未来的化合物靶标表征数据中挖掘更高应用价值，我们搭建了一款名为药物靶标公共库（Drug Target Commons, DTC）的开放数据网络平台，该平台集成了众包式化合物-靶标生物活性数据注释、标准化、整理以及资源内部整合的相关工具。我们通过多个与药物发现及药物重定位应用相关的案例，展示了DTC的独特价值，并邀请研究人员加入这一社区共建项目，以提升化合物生物活性数据的复用率与拓展性。 引用： 《药物靶标公共库：共建药物-靶标相互作用共识知识库的社区行动》 Cell Chem Biol. 2018 Feb 15;25(2):224-229.e2. doi: 10.1016/j.chembiol.2017.11.009