A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells - data repository

Single-cell RNA sequencing data from five single-HSC-derived murine hematopoietic systems, as well as two polyclonal controls. The resulting clonally-resolved hematopoietic bone marrow atlas (scBM_atlas.rds) consists of 76,863 high-quality cells and covers all major hematopoietic cell types, including differentiation tracks (slingshot.rds) from the most immature HSCs to all lineage-committed progenitors (HSPCs.rds) and their continued maturation into blood and immune cells.本数据集包含源自5个单一造血干细胞（hematopoietic stem cell, HSC）构建的小鼠造血系统，以及2份多克隆对照样本的单细胞RNA测序（single-cell RNA sequencing）数据。最终得到的克隆解析型造血骨髓图谱（scBM_atlas.rds）共包含76863个高质量细胞，覆盖所有主要造血细胞类型，涵盖从最不成熟的造血干细胞至各类谱系定向祖细胞（HSPCs.rds）的分化轨迹（slingshot.rds），以及这些细胞后续向血液细胞与免疫细胞的成熟进程。