OPM brain spinal cord data (1/2)

This dataset contains concurrent brain and spinal cord recordings made with optically pumped magnetometers (OPMs), together with surface electromyography (EMG), acquired during rest and sustained voluntary hand contraction (abductor pollicis brevis, APB). Due to file size, data from 7 participants is available in this repository; data from the remaining 2 participants is available at 10.5281/zenodo.19029856. Code for preprocessing data and analysing brain–spinal cord–muscle functional connectivity is available at https://github.com/meaghanspedden/brainspine-connectivity. The BEM meshes, lead fields, and MNI-to-native transformation matrix required for source reconstruction and figure generation are provided in the Leadfields meshes/ folder of this repository. Pre-computed results files for regenerating the main paper figures without re-running the full pipeline are available in the forGeneratingFigures/ folder at 10.5281/zenodo.19029856. Experimental task Participants lay supine in a magnetically shielded room (MSR) wearing a custom 3D-printed scanner-cast. They performed alternating two-minute blocks of weak sustained right thumb abduction (~15% of maximal voluntary contraction) and rest, for five cycles. OPM recordings Brain and spinal cord magnetic fields were recorded simultaneously using 64 triaxial QuSpin Neuro-1 third-generation OPM sensors (QuSpin Inc., Louisville, CO, USA), mounted in a custom scanner-cast covering the scalp, neck, chest, and back. The system has an intrinsic bandwidth of 0–135 Hz. Experiments were conducted in a 438 × 338 × 218 cm MSR (Magnetic Shields Ltd, UK). Data were acquired at 1500 Hz. EMG recordings Surface EMG was recorded from the right APB muscle at 1000 Hz using pairs of surface electrodes (Ambu Ltd, Denmark), with a reference electrode at the right wrist. Signals were amplified and digitised outside the MSR using a BrainAmp system (Brain Products, Germany) and synchronised to OPM data via TTL pulse. Forward models and source reconstruction A five-compartment boundary element model (BEM) of the spinal cord was constructed using structural MRI (3T Siemens Prisma, 1.5 mm isotropic) from one participant, including torso,vertebral bone, and spinal cord compartments. Lung and heart meshes produced using ECGsim (https://www.ecgsim.org/) were co-registered to this coordinate space. BEM lead fields were computed using the Helsinki BEM Framework (https://github.com/MattiStenroos/hbf_lc_p) and the msg_coreg toolbox ((https://github.com/maikeschmidt/msg_coreg). Notes Participant OP00212 has full anatomical co-registration and individual forward models; the remaining participants use the common reference anatomy. /├── Leadfields_meshes/ # Shared anatomical and forward model files│ ├── BEM meshes # Five-compartment spinal cord BEM meshes│ ├── Leadfields # Precomputed OPM lead fields (brain and spinal cord)│ └── MNI_to_native_transform # Transformation matrix from MNI to native space│└── sub-XX/ # One folder per participant (XX = participant ID) └── ses-001/ ├── emg/ # Surface EMG data (right APB muscle) │ ├── *.vhdr # BrainVision header file │ ├── *.eeg # BrainVision binary data file │ └── *.vmrk # BrainVision marker file └── meg/ # OPM recordings ├── *.tsv # Sensor position files ├── *.lvm # Raw OPM data ├── *.dat # Preprocessed OPM data (SPM .dat file) └── *.mat # Preprocessed OPM data (SPM .mat file)本数据集包含同步采集的脑与脊髓信号及表面肌电（electromyography, EMG）数据，采集所用设备为光泵磁力仪（optically pumped magnetometers, OPMs），任务涵盖静息状态与持续自主手部收缩（拇短展肌，abductor pollicis brevis, APB）。受文件体积限制，本仓库仅收录7名受试者的数据；剩余2名受试者的数据可通过链接10.5281/zenodo.19029856获取。 用于预处理数据、分析脑-脊髓-肌肉功能连通性的代码已开源于https://github.com/meaghanspedden/brainspine-connectivity。本仓库的Leadfields meshes/文件夹中提供了源重构与绘图所需的边界元模型（boundary element model, BEM）网格、引线场（lead fields）以及MNI空间到个体原生空间的转换矩阵。无需完整运行分析流程即可复现论文主图的预计算结果文件，可在10.5281/zenodo.19029856的forGeneratingFigures/文件夹中获取。 ### 实验范式 受试者仰卧于磁屏蔽室（magnetically shielded room, MSR）内，佩戴定制3D打印的扫描仪适配头套。他们完成5个循环的交替任务：每次为持续2分钟的轻度右手拇指外展（约为最大自主收缩力的15%）与静息状态。 ### 光泵磁力仪采集 脑与脊髓的磁场信号通过64个三轴QuSpin Neuro-1第三代光泵磁力仪传感器（QuSpin Inc., 美国科罗拉多州路易斯维尔）同步采集，传感器安装于覆盖头皮、颈部、胸部与背部的定制扫描仪适配头套中。该系统固有带宽为0–135 Hz。实验在尺寸为438 × 338 × 218 cm的磁屏蔽室（英国Magnetic Shields Ltd）内开展，数据采样率为1500 Hz。 ### 表面肌电采集 使用成对的表面电极（丹麦Ambu Ltd）从右侧拇短展肌采集表面肌电信号，采样率为1000 Hz，参考电极置于右侧腕部。信号经德国Brain Products公司的BrainAmp系统放大并数字化后，通过TTL脉冲与光泵磁力仪数据实现同步，该设备放置于磁屏蔽室外。 ### 正向模型与源重构 基于1名受试者的结构磁共振成像（3T Siemens Prisma，各向同性分辨率1.5 mm）构建了包含躯干、椎骨与脊髓共5个室的脊髓边界元模型（BEM）。使用ECGsim（https://www.ecgsim.org/）生成的肺与心脏网格被配准至该坐标空间。边界元引线场通过赫尔辛基边界元框架（https://github.com/MattiStenroos/hbf_lc_p）与msg_coreg工具箱（https://github.com/maikeschmidt/msg_coreg）计算得到。 ### 备注 受试者OP00212拥有完整的解剖配准与个体正向模型；其余受试者均使用统一的参考解剖结构。 /├── Leadfields meshes/ # 共享解剖学与正向模型文件 │ ├── BEM meshes # 五室脊髓边界元模型网格 │ ├── Leadfields # 预计算的光泵磁力仪引线场（脑与脊髓） │ └── MNI_to_native_transform # MNI空间到个体原生空间的转换矩阵 │└── sub-XX/ # 每名受试者对应一个文件夹（XX为受试者ID） └── ses-001/ ├── emg/ # 表面肌电数据（右侧拇短展肌） │ ├── *.vhdr # BrainVision头文件 │ ├── *.eeg # BrainVision二进制数据文件 │ └── *.vmrk # BrainVision标记文件 └── meg/ # 光泵磁力仪采集数据 ├── *.tsv # 传感器位置文件 ├── *.lvm # 原始光泵磁力仪数据 ├── *.dat # 预处理后的光泵磁力仪数据（SPM .dat文件） └── *.mat # 预处理后的光泵磁力仪数据（SPM .mat文件）